Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity
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چکیده
منابع مشابه
Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity
Aggressive cancers are characterized by hypoxia, which is a key driver of tumor development and treatment resistance. Proteins specifically expressed in the hypoxic tumor microenvironment thus represent interesting candidates for targeted drug delivery strategies. Carbonic anhydrase (CAIX) has been identified as an attractive treatment target as it is highly hypoxia specific and expressed at th...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.16921